Response to Comment on: Vila et al. B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men. Diabetes 2012;61:2592-2596
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چکیده
منابع مشابه
Response to Comment on: Vila et al. B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men. Diabetes 2012;61:2592–2596
Vila et al. (1) reported that brain natriuretic peptide (BNP) infusions reduce total and acylated-ghrelin levels while increasing satiety. Since ghrelin acts orexigenic, the authors conclude that BNP might indirectly regulate food intake in conditions associated with excessive BNP levels, such as in heart failure. The hypothesis is provocative but ignores the complex metabolic actions of natriu...
متن کاملB-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from ventricular cardiomyocytes. The pathophysiological mechanisms linking heart failure and appetite regulation remain unknown. In this study, we investigated the impact of intravenous BNP administration on appetite-regulating hormones and subjective ratings of hunger and satiety in 10 he...
متن کاملResponse to Comment on Lee et al. Diabetes 2015;64:2836-2846. Comment on Roberts et al. Diabetes 2015;64:471-484.
We thank Kruszelnicka and Surdacki (1) for their insightful comments on our recent article (2), which suggested a favorable metabolic effect of endothelial nitric oxide (NO) that stimulates the polarization of hepatic resident macrophages toward an anti-inflammatory M2 phenotype. Kruszelnicka and Surdacki ask whether the nitrate-nitrite pathway exerts beneficial metabolic effects in the liver. ...
متن کاملComment on: Lazo et al. NH2-Terminal Pro–Brain Natriuretic Peptide and Risk of Diabetes. Diabetes 2013;62:3189–3193
Lazo et al. (1) reported that plasma NH2-terminal pro–brain natriuretic peptide (NT-proBNP) levels, a cleavage product of brain natriuretic peptide (BNP), are inversely associated with diabetes risk in ;7,800 healthy patients over a period of 12 years. In line with this, genetic evidence suggests a protective effect of BNP on diabetes risk (2). So far, mechanistic insight is lacking on how natr...
متن کاملComment on: Chang et al. A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes. Diabetes Care 2012;35:2594–2596
I read the article by Chang et al. (1) with some interest. However, there are several aspects of their article that I believe need further explanation. The authors have previously published data on the same cohort of patients reporting no change in symptoms over a 12-year period (2). Out of their original cohort of 86 subjects, current data are only presented on 15% or 13 subjects. While the au...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2012
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db12-1156